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KMID : 0882420150890040478
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Korean Journal of Medicine
2015 Volume.89 No. 4 p.478 ~ p.481
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Distal Renal Tubular Acidosis Caused by Tacrolimus in a Systemic Lupus Erythematosus Patient: A Case Report
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Kim Hae-Koo
Lee Ji-Hyun
Ku In-Hye
Kang Sung-Min
Choi Joon-Sul
Kim Sung-Jun
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Abstract
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Renal tubular acidosis (RTA) refers to a group of disorders involving transport defects in bicarbonate reabsorption or hydrogen excretion. Features like metabolic acidosis with a normal anion gap, neurological symptoms, and electrolyte imbalances indicate RTA. Kidney transplantation, cirrhosis, sickle cell anemia, medications, and autoimmune diseases, particularly Sjogren’s syndrome and rheumatoid arthritis, are related to RTA. We encountered a rare case of a patient with systemic lupus erythematosus accompanied by RTA secondary to tacrolimus administration, who had muscle weakness and paralysis. Her symptoms improved after discontinuing tacrolimus and correcting the acidosis and potassium levels. Here, we report on this case and review the relevant literature.
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KEYWORD
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Acidosis, Renal tubular, Tacrolimus, Lupus erythematosus, Systemic
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